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Serious gastrointestinal adverse events were uncommon but did occur, reinforcing the importance of clinical monitoring
However, in the absence of acute injury, SDF-1 signaling may impair cardiac contractility [70, 71]
Simple adjustments, like avoiding heavy meals before bedtime or limiting trigger foods such as caffeine, citrus, and spicy dishes, may help reduce symptoms of gastrointestinal issues
As a result, the GLP-1 agonists industry remains a two-player race at the molecule level, with semaglutide and tirzepatide setting efficacy benchmarks that newer entrants must match or exceed
The company cut Canadian list prices for Mounjaro and Zepbound by 20% or more, with the 2.5 mg and 5 mg doses now set at $300 CAD per four-week supply [Source: glp1prices.ca/glp1-news/eli-lilly-cuts-mounjaro-zepbound-prices-20-percent-canada-2026]
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